Centro Universitario San Marcos is a professional training institution, with presence according to enrollment in 2022 in Chiapas (257) and Estado de México (177), with most of the student body centered in the municipalities of San Cristóbal de las Casas (257) and Calimaya (177).
In 2022, Centro Universitario San Marcos had 434 enrolled, of which 53% (228) were men and 47% (206) were women.
In 2022, the institution had 109 undergraduates, of these 60 were men and 49 women. The areas with the most graduates were Social sciences and law (46), Administration and business (44), and Education (17).